亚愽全站

科研队伍
殷昊

 

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最后学位:博士 (PhD,美国科罗拉多大学医学中心)

职称职务:教授、博导

专业方向:遗传学、药学

研究方向:基因编辑、核酸药物

电话号码:027-68750332

电子邮件:haoyin@whu.edu.cn

 

 

教育经历

1999-2003  南京大学生命科学学院,学士

2004-2010  美国科罗拉多大学医学中心 (University of Colorado Anschutz Medical Campus),博士

 

工作经历与任职

2010-2016 美国麻省理工学院 (Massachusetts Institute of Technology),博士后

     (2011-2012Alnylam Pharmaceuticals任兼职访问研究员)

2016-2018 美国福泰制药 (Vertex Pharmaceuticals),研究员

2018-   亚愽全站,教授

 

获奖情况

2009  国家优秀自费留学生奖学金

2009  Award for Outstanding Research, University of Colorado

2010  The American Society for Pharmacology and Experimental Therapeutics Best Abstract Award

2010  The American Society for Pharmacology and Experimental Therapeutics Travel Award

2012  MGH/Harvard Future Leaders in Cancer Research and Translational Medicine, MGH Cancer Center

2016  Travel Award, The 21st International Symposium on Microsomes and Drug Oxidations

2016  Meritorious Abstract Travel Award, American Society of Gene & Cell Therapy (ASGCT)

 

学术兼职

学术杂志审稿人:

Nature Biotechnology, Science Advances, Nature Communications, Journal of the American Chemical Society (JACS), Advanced Science, Chemical Reviews, Molecular Therapy, Nucleic Acids Research 50多种学术杂志。

 

研究领域

基因编辑工具 CRISPR 系统可精确修复基因,治疗遗传。腥拘约膊『桶┲⒌戎卮蠹膊。本课题组综合应用分子生物学、生物信息学、模式动物,和生物材料等手段进行研究。方向包括:

1 新型基因编辑系统      

2 新型核酸药物     

3 细胞和基因治疗

 

发表论文、专利和学术报告概况

1、已在国际刊物发表和接收论文45篇,被引用约10000余次(google scholar),H index 32,10篇论文为高被引论文。

2、多项研究成果被美国及国际主流媒体报道和 Nature 系列杂志专文评述。

3、申请美国和国际专利 9 项,已获批准 3 项。

 

代表性论文(* 通讯作者、# 同等贡献)

1. Lu S#, Tong X#, Han Y#, Zhang K, Zhang Y, Chen Q, Duan J, Lei X, Huang M, Qiu Y, Zhang DY, Zhou X, Zhang Y*, Yin H*, Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a, Nature Biomedical Engineering, 2022 Mar; 6(3): 286-297.

        Nature Biomedical Engineering编辑部评述 “Rethinking diagnostics for pandemic readiness”

2. Wang J#, He Z#, Wang G#, Zhang R#, Duan J, Gao P, Lei X, Qiu H, Zhang C, Zhang Y, Yin H*, Efficient targeted insertion of large DNA fragments without DNA donor, Nature Methods, 2022, online.

3. Wang L#, Xue W#, Zhang H#, Gao R#, Qiu H#, Wei J, Zhou L, Lei YN, Wu X, Li X, Liu C, Wu J, Chen Q, Ma H, Huang X, Cai C, Zhang Y, Yang B*, Yin H*, Yang L*, Chen J*, Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations. Nature Cell Biology. 2021 May;23(5):552-563.

4. Song CQ#, Jiang T#, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR*, Yin H*, Xue W*, Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering. 2020 Jan;4(1):125-130.

专文评述: Nature Biomedical Engineering “Correcting tyrosinaemia via a point mutation”  

                  Nature Biomedical Engineering “Towards better base editing”

F1000 推荐

5. Lu S#, Li F#, Chen Q, Wu J, Duan J, Lei X, Zhang Y, Zhao D, Bu Z*, Yin H*, Rapid detection of African swine fever virus using Cas12a-based portable paper diagnostics. Cell Discovery 2020 volume 6:18.

6. Yin H*, Xue W*, Anderson DG* CRISPR-Cas: a tool for cancer research and therapeutics. Nature Reviews Clinical Oncology. 2019 May;16(5):281-295.

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文选集

7. Chen Q, Zhang Y*, Yin H*, Recent advances in chemical modifications of guide RNA, mRNA and donor template for CRISPR-mediated genome editing. Advanced Drug Delivery Reviews 2021 Jan;168:246-258.

8. Wu J, Yin H*. Engineering guide RNA to reduce the off-target effects of CRISPR. Journal of Genetics and Genomics. 2019 Nov 20;46(11):523-529.

9. Zhang HX, Zhang Y*, Yin H*. Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9. Molecular Therapy. 2019 Apr 10;27(4):735-746.

10. Yin H#, Song CQ#, Suresh S, Kwan SY, Wu Q, Walsh S, Ding J, Bogorad RL, Zhu LJ,Wolfe SA, Koteliansky V, Xue W, Langer R, Anderson DG,Partial DNA-guided Cas9 enables genome editing with reduced off-target activity. Nature Chemical Biology.2018, 14(3):311-316.

专文评述: Nature Catalysis “Better guidance is cheaper”

                  BioCentury | Altering Cas9 and its guide for fewer off-target edits.

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文选集

11. Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing. Nature Biotechnology 2017, 35(12):1179-1187.

*媒体报道:Featured by VOICE of America / US Researchers Use Nanotech, Gene Editing to Edit Cholesterol Gene VICE / CRISPR Can Now Edit Genes Using Nanoparticles Instead of Viruses Yahoo News / CNBC / Nanotech, gene editing used to edit cholesterol gene-US study/ Genetic Engineering & Biotechnology News / CRISPR/Cas9 Delivery Goes Nano with Enhanced Guide RNA Fiercebiotech / MIT scientists propose a safer way to edit genes with CRISPR / MIT News / Science Daily / Bioscience Technology / Medical News Today/Business Insider UK / The Medical News / Phys.org.

F1000 推荐

12. Yin H, Kauffman KJ and Anderson DG. Delivery technologies for genome editing. Nature Reviews Drug Discovery 2017, 16(6): 387-399.

13. Yin H, Song CQ, Dorkin JR, Zhu L, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi M, Walsh S, Bogorad R, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe S, Langer R, Xue W and Anderson DG. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nature Biotechnology 2016,34(3):328-33.

*媒体报道:Featured by MIT News / Science Daily / Bioscience Technology / Medical News Today / Deutsches ?rzteblatt / Nanowerk / Nanotechnology Now /The Medical News / Phys.org

14. Yin H#, Bogorad RL#, Barnes C, Walsh S, Zhuang I, Nonaka H, Ruda V, Kuchimanchi S, Nechev L, Akinc A, Xue W, Zerial M, Langer R, Anderson DG, Koteliansky V. RNAi-nanoparticulate manipulation of gene expression as a new functional genomics tool in the liver. Journal of Hepatology 2016, 64(4):899-907.

15. Mou H, Kennedy Z, Anderson DG, Yin H*, and Xue W*, Precision cancer mouse models through genome editing with CRISPR-Cas9. Genome Medicine 2015, 7(1):53.

16. Yin H#, Xue W#, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG (2014) Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology 2014, 32(6):551-3.

*100 top stories of 2014 by Discover Magazine as “A Giant Step for Gene Surgery”

*Top Ten Genetics Stories for 2014: Incredible Achievements, by the DNA Exchange

*专文评述: Nature Medicine (CRISPR technology for gene therapy) | 封面故事Science–Business eXchange of Nature Publishing Group | BioTechniques

*媒体报道:Featured by MIT News /英国独立报头版报道/ Fox News / The Times of India / Science Daily / Medical daily / The Voice of Russia / Phys.org /

F1000 推荐

入选Nature庆祝基因编辑荣获2020年诺贝尔奖的百篇论文选集

17. Xue W#, Chen S#, Yin H#, Tammela T, Joshi N, Papagiannakopoulos T, Cai W, Yang G, Bronson R, Crowley D, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature 2014, 514(7522):380-4.

*专文评述: Hepatology (Cutting short the path to murine liver cancer models)

*媒体报道: Featured by MIT News / Science Daily / Medical Press / Newswise / F1000Prime Recommendation.

18. Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nature Reviews Genetics 2014, 15(8):541-55.

19. Bogorad RL#, Yin H#, Zeigerer A, Nonaka H, Ruda VM, Zerial M, Anderson DG, Koteliansky V Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. Nature Communications 2014, 5:3869.

*专文评述: Nature Reviews Gastroenterology & Hepatology (Loss of integrin β1 impairs liver regeneration and HCC progression)

20. Yin H, Cheng L, Holt M, Hail N, Jr., Maclaren R, Ju C, “Lactoferrin protects against acetaminophen-induced liver injury in mice”, Hepatology 2010, doi: 10.1002/hep.23476.

21. Yin H, Cheng L, Langenbach R, Ju C, “Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury”, Hepatology 2007, doi: 10.1002/hep.21493.

 

发表著作

"Genome Editing for Genetic Lung Diseases" Pharmaceutical Inhalation Aerosol Technology, Third Edition

Chimeric DNA-RNA Guide RNA Designs. Methods Mol Biol. 2021;2162:79-85.

 

实验室网站见:http://yinlab.team/

 

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